A thixotropic polyglycerol sebacate-based supramolecular hydrogel showing UCST behavior

摘要: Polyglycerol sebacate (PGS) is a relatively new biodegradable and elastomeric material that exhibits superior biocompatibility, modulus comparable to human soft tissue, linear biodegradation. However, the high hydrophobicity, low water uptake percentage extreme synthesis conditions of PGS pose as hindrance its use in cellular biology, biomedical other applications. We were able modify using atom transfer radical polymerization (ATRP) by synthesizing macroinitiator, allowing us improve PGS's properties or introduce PGS. This macroinitiator would enable building robust platform PGS-based copolymers with monomers methacrylates, styrenes methacrylamide families. demonstrated feasibility this PEGMEMA monomer synthesize PGS–PEGMEMA created PGS–PEGMEMA/αCD supramolecular hydrogel system. exhibited tunable, UCST less than 90 °C, minimum gelation concentration 5.2%, rapid self-healing ability (∼100 kPa) tissue. system injectable yet strong enough provide support – features, making it very suitable candidate vehicle for sustained-release drug delivery, cell tissue engineering scaffold well cosmetics skincare