Functional neuroimaging in obsessive-compulsive disorder.

摘要: Background and Aim: Obsessive-compulsive disorder (OCD) is a severe, highly prevalent chronically disabling psychiatric that usually emerges during childhood or adolescence. This paper aims to review the literature on functional neuroimaging in OCD, analysing reported dysfunctional connectivity corticostriatothalamocortical circuitry. Method: study included papers published peer-reviewed journals dealing with imaging OCD. Results: Striatal dysfunction, mainly of caudate nucleus, leads inefficient thalamic gating, resulting hyperactivity within orbitofrontal cortex (intrusive thoughts) anterior cingulate (non-specific anxiety). Compulsions consist ritualistic behaviours performed recruit striatum neutralise unwanted thoughts anxiety. Functional findings are discussed against background specific cognitive impairments, regarding visuospatial processing, executive functioning motor speed. Cognitive deficits partial specific, matching data. Conclusions: Several studies have targeted brain regions hypothesised be involved pathogenesis showing existence Improvements spatial resolution techniques may contribute better understanding neurocircuitry OCD other anxiety disorders.