Rapid chiral separation of racemic cetirizine in human plasma using subcritical fluid chromatography-tandem mass spectrometry.

作者: Han Young Eom , Myunghee Kang , Seung Woo Kang , Unyong Kim , Joon Hyuk Suh

DOI: 10.1016/J.JPBA.2015.09.012

关键词: Analytical chemistryDetection limitResolution (mass spectrometry)Solid phase extractionElectrospray ionizationTandem mass spectrometryChromatographySample preparationChemistryLevocetirizineMass spectrometry

摘要: … In the present study, we developed and validated a rapid and reliable method for chiral separation of racemic cetirizine and determination of levocetirizine in human plasma using …

参考文章(43)
Hassan Y. Aboul-Enein, Irving W. Wainer, The Impact of Stereochemistry on Drug Development and Use ,(1997)
T A Berger, Packed Column SFC ,(1995)
E. J. Ari�ns, Stereochemistry, a basis for sophisticated nonsense in pharmacokinetics and clinical pharmacology European Journal of Clinical Pharmacology. ,vol. 26, pp. 663- 668 ,(1984) , 10.1007/BF00541922
G. Subramanian, Chiral separation techniques : a practical approach Wiley-VCH. ,(2001)
Y Aboul-Enein Hassan, Imran Ali, None, Chiral Separations By Liquid Chromatography And Related Technologies ,(2003)
M. Reist, B. Testa, P.-A. Carrupt, Drug Racemization and Its Significance in Pharmaceutical Research Enantiomer. ,vol. 153, pp. 91- 112 ,(2003) , 10.1007/978-3-642-55842-9_4
L. Toribio, M.J. del Nozal, J.L. Bernal, C. Cristofol, C. Alonso, Study of the enantiomeric separation of oxfendazole and cetirizine using subcritical fluid chromatography on an amylose-based column. Journal of Chromatography A. ,vol. 1121, pp. 268- 273 ,(2006) , 10.1016/J.CHROMA.2006.04.008
Yun K Ye, Kenneth G Lynam, Rodger W Stringham, Effect of amine mobile phase additives on chiral subcritical fluid chromatography using polysaccharide stationary phases. Journal of Chromatography A. ,vol. 1041, pp. 211- 217 ,(2004) , 10.1016/J.CHROMA.2004.04.060