Bacterial meningitis among children under the age of 2 years in a high human immunodeficiency virus prevalence area after Haemophilus influenzae type b vaccine introduction.

摘要: Aim:  The aim of this study was to describe bacterial causes meningitis among children < 2 years in a high human immunodeficiency virus (HIV) prevalence area after introduction routine Haemophilus influenzae type b vaccination. Methods:  Data collected between April 2003 and December 2008 were extracted from surveillance database medical records admitted Mbarara Hospital, Uganda with suspected meningitis. HIV infection confirmed using rapid tests polymerase chain reaction by cerebrospinal fluid culture. Results:  Between 2008, 1464 under 5 years which 1235 (84.4%) had collected; 894 (72.4%) these samples 2 years. Of the samples, 64 (7.2%) grew an organism including Streptococcus pneumoniae (26; 41%), Salmonella species (20; 31%), H. (6; 9%) coliforms (7; 11%), five (8%) contaminants that are all coagulase negative Staphylococcus. children, 468 (52.3%) tested for HIV; 16.7% positive. Fifty-one pathogenic isolate treatment outcome, 23 (45%) died; 13 (56.6%) deaths due S. pneumoniae, eight (34.8%) spp., one (4.3%) coliforms. associated threefold increase mortality, increased likelihood decreased malaria parasitaemia. Conclusion:  Following vaccine introduction, S. spp. major Uganda. Pneumococcal conjugate vaccines reduction mother child transmission could reduce observed mortality.