Public health aspects of serum cholesterol

摘要: textabstractIn the beginning of this century Anitschkow and De Langen started pioneering work concerning relation between cholesterol coronary heart disease. Both showed that there was a possible in diet, blood cholesterol levels atherosclerosis. It took until second half twentieth century before large-scale population based studies, like Framingham Study and the Seven Countries Study, were to investigate serum cholesterol disease. These studies positive associations serum incidence mortality from coronary disease middle-aged men. Since then, other large epidemiological have shown total is positively associated HDL inversely associated with disease mortality men. Quantifying effect lowering interventions on for example incidence The Netherlands an important public health issue. Total Dutch are relatively high did not substantially decrease nineteen nineties. To quantify the amount health gain can be achieved through lowering, additional information has gathered. First, recent trends total and prevalences hypercholesterolemia low HDL cholesterol described. Second, more evidence impact in elderly men women collected. well known and HDL and women, but it still unclear whether holds elderly. Third, risk functions predict absolute risk and women developed. However, elderly not clear these valid tool prediction. This know because cholesterol treatment nowadays level risk, taking profile individual into account.