Detection of cerebral reorganization associated with degenerative cervical myelopathy using diffusion spectral imaging (DSI).
作者： Benjamin M. Ellingson , Langston T. Holly , Catalina Raymond , Jingwen Yao , Chencai Wang
DOI: 10.1016/J.JOCN.2021.01.011
关键词: Asymptomatic 、 Cardiology 、 Orthopedic surgery 、 Fractional anisotropy 、 Myelopathy 、 Spinal cord 、 Medicine 、 Internal medicine 、 Cervical spondylosis 、 Spinal cord compression 、 Spinal Cord Disorder
摘要: Abstract Degenerative Cervical Myelopathy (DCM) is a spinal cord disorder that causes significant physical disabilities in older patients. While most DCM research focuses on the cord, widespread reorganization of brain may occur to compensate for functional impairment. This observational study used diffusion spectrum imaging (DSI) examine cerebral white matter associated with neurological impairment as measured by modified Japanese Orthopedic Association (mJOA), and severity neck disability Neck Disability Index (NDI) score. A total 47 patients were included cervical spondylosis (CS) cohort: 38 (mean mJOA = 14.6, mean NDI = 12.0), 9 neurologically asymptomatic compression (mJOA = 18, NDI = 7.0). 28 healthy volunteers (HCs) served control group. Lower generalized fractional anisotropy (GFA) was observed throughout much compared HCs (p
sci-hub.st 参考文章(50)
Yun Dong, Langston T. Holly, Richard Albistegui-Dubois, Xiaohong Yan, Jonathan Marehbian, Jennifer M. Newton, Bruce H. Dobkin, Compensatory cerebral adaptations before and evolving changes after surgical decompression in cervical spondylotic myelopathy. Journal of Neurosurgery. ,vol. 9, pp. 538- 551 ,(2008) , 10.3171/SPI.2008.10.0831
Howard Vernon, The Neck Disability Index: State-of-the-Art, 1991-2008 Journal of Manipulative and Physiological Therapeutics. ,vol. 31, pp. 491- 502 ,(2008) , 10.1016/J.JMPT.2008.08.006
Langston T. Holly, Benjamin M. Ellingson, Noriko Salamon, Metabolic Imaging Using Proton Magnetic Spectroscopy as a Predictor of Outcome After Surgery for Cervical Spondylotic Myelopathy. Clinical spine surgery. ,vol. 30, pp. 1- ,(2015) , 10.1097/BSD.0000000000000248
P.J. Basser, J. Mattiello, D. LeBihan, MR diffusion tensor spectroscopy and imaging. Biophysical Journal. ,vol. 66, pp. 259- 267 ,(1994) , 10.1016/S0006-3495(94)80775-1
Eun Jin Yoon, Yu Kyeong Kim, Hyung Ik Shin, Youngjo Lee, Sang Eun Kim, Cortical and white matter alterations in patients with neuropathic pain after spinal cord injury. Brain Research. ,vol. 1540, pp. 64- 73 ,(2013) , 10.1016/J.BRAINRES.2013.10.007
Jaivijay Ramu, Kurt H. Bockhorst, Kishore V. Mogatadakala, Ponnada A. Narayana, Functional magnetic resonance imaging in rodents: Methodology and application to spinal cord injury. Journal of Neuroscience Research. ,vol. 84, pp. 1235- 1244 ,(2006) , 10.1002/JNR.21030
Van J. Wedeen, Patric Hagmann, Wen-Yih Isaac Tseng, Timothy G. Reese, Robert M. Weisskoff, Mapping complex tissue architecture with diffusion spectrum magnetic resonance imaging. Magnetic Resonance in Medicine. ,vol. 54, pp. 1377- 1386 ,(2005) , 10.1002/MRM.20642
Jaivijay Ramu, Kurt H. Bockhorst, Raymond J. Grill, Kishore V. Mogatadakala, Ponnada A. Narayana, Cortical reorganization in NT3-treated experimental spinal cord injury: Functional magnetic resonance imaging. Experimental Neurology. ,vol. 204, pp. 58- 65 ,(2007) , 10.1016/J.EXPNEUROL.2006.09.015
Michael G. Fehlings, Ghassan Skaf, A Review of the Pathophysiology of Cervical Spondylotic Myelopathy With Insights for Potential Novel Mechanisms Drawn From Traumatic Spinal Cord Injury Spine. ,vol. 23, pp. 2730- 2736 ,(1998) , 10.1097/00007632-199812150-00012
A. Curt, M. Bruehlmeier, K.L. Leenders, U. Roelcke, V. Dietz, Differential effect of spinal cord injury and functional impairment on human brain activation. Journal of Neurotrauma. ,vol. 19, pp. 43- 51 ,(2002) , 10.1089/089771502753460222