Cutaneous Opioid System
作者： Andrzej T. Slominski , Michal A. Zmijewski , Cezary Skobowiat , Blazej Zbytek , Radomir M. Slominski
DOI: 10.1007/978-3-642-19683-6_10
关键词: Dorsal root ganglion 、 Endorphins 、 Proopiomelanocortin 、 Proenkephalin 、 Dynorphin 、 Dynorphin A 、 Proteolysis 、 Internal medicine 、 Endocrinology 、 Chemistry 、 Opioid peptide
摘要: Endogenous opioid peptides derive from four different precursor proteins. Proopiomelanocortin (POMC) yields ACTH and endorphins, mainly β-endorphin (β-END). Proenkephalin (PENK) generates enkephalins (ENK), predominantly Met-enkephalin (MENK) Leu-enkephalin (LENK). The proteolysis of prodynorphin (PDYN) results in the formation dynorphin A (DYN A) B B) (Przewlocki 2004; Przewlocki Przewlocka 2005). Other POMC derivatives are endomorphins which cleavage products a larger molecule that yet has not been identified (Fichna et al. 2007).
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