Acetyl and butyrylcholinesterase-inhibiting triterpenoid alkaloids from Buxus papillosa.

摘要: Abstract Three triterpenoid alkaloids, buxakashmiramine [(20S)-20-dimethylamino-4′,6′-dimethoxy-5′-hydroxybenzoylamino-3β-methyl-buxan-31-ol] ( 1 ), buxakarachiamine [(20S)-20-dimethylamino-2′-hydroxy-3β-methyl-3′-methyl-butanoylamino-9,10-seco-buxa-9(11), 10(19)-dien-31-ol] 2 ) and buxahejramine [(20S)-20-dimethylamino-2′-hydroxy-3β-methyl-3′-methyl-pentanoylamino-9,10-seco-buxa-9(11), (3) were isolated from the leaves of Buxus papillosa. Four known bases, cycloprotobuxine-C (4), cyclovirobuxeine-A (5), cyclomicrophylline-A (6) semperviraminol (7) for first time this species. Their structures established through extensive spectroscopic studies. Most these compounds exhibited anticholinesterase activity. Download : full-size image Fig. . Important HMBC interactions observed compound 1.