Plaque Disruption and Thrombosis: Models to Evaluate Acute Cardiovascular Events

摘要: Although the concept of plaque disruption leading to arterial thrombosis is not novel, it was accepted as a critical pathophysiologic event for many years. In fact, early publications suggested and be mechanism underlying acute cardiovascular events [1, 2, 3, 4]. A historical report in 1912 provides an example that demonstrated by autopsy performed immediately after sudden death [1],[5]. subsequent Herrick described ulcerated atheromatous extruding into lumen plugged coronary artery. Two decades ago, similar observations were made DeWood et al. patients undergoing artery bypass surgery myocardial infraction