Oxidative stress in major depressive and anxiety disorders, and the association with antidepressant use; results from a large adult cohort.

摘要: Background: Oxidative stress has been implicated in the pathophysiology of major depressive disorder (MDD) and anxiety disorders may be influenced by antidepressant use. This study investigated association oxidative stress, measured plasma levels F2-isoprostanes 8-hydroxy-2′-deoxyguanosine (8-OHdG) reflecting lipid DNA damage respectively, with MDD, use a large cohort. Method: Data was derived from Netherlands Study Depression Anxiety including patients current (N = 1619) or remitted 610) MDD and/or disorder(s) (of which N 704 users) 612 controls. Diagnoses were established Composite International Diagnostic Interview. Plasma 8-OHdG using LC-MS/MS. ANCOVA performed adjusted for sampling, sociodemographic, health lifestyle variables. Results: did not differ between controls patients, Patients had lower (mean 42.1 pmol/l, 95% CI 40.4-43.8) compared to (45.0 42.9-47.2; p < 0.001) after adjustment sociodemographics lifestyle, but these differences disappeared further (p 0.562). Antidepressant users (38.2 36.5-39.9) (44.9 43.2-46.6; Cohen's d 0.21, 0.001). comparable across (MDD disorders), all types (SSRIs, TCAs, other antidepressants). Conclusion: Contrary previous findings this large-scale found no increased disorders. associated damage, suggesting antidepressants have antioxidant effects.