Expression of a Gene Cluster kaiABC as a Circadian Feedback Process in Cyanobacteria
作者： Masahiro Ishiura , Shinsuke Kutsuna , Setsuyuki Aoki , Hideo Iwasaki , Carol R Andersson
DOI: 10.1126/SCIENCE.281.5382.1519
关键词: KaiC 、 Synechococcus 、 Biology 、 KaiA 、 Genetics 、 Circadian clock 、 Cyanobacteria 、 Bacterial circadian rhythms 、 Gene 、 Circadian rhythm
摘要: Cyanobacteria are the simplest organisms known to have a circadian clock. A circadian clock gene cluster kaiABC was cloned from the cyanobacterium Synechococcus. Nineteen clock mutations were mapped to the three kai genes. Promoter activities upstream of the kaiA and kaiB genes showed circadian rhythms of expression, and both kaiA and kaiBC messenger RNAs displayed circadian cycling. Inactivation of any single kai gene abolished these rhythms and reduced kaiBC-promoter activity. Continuous kaiC overexpression …
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