Anti-neutrophil cytoplasmic autoantibodies: a renewed paradigm in periodontal disease pathogenesis?
作者： CG Dileep Sharma , AR Pradeep , None
关键词: Periodontal disease 、 Immunology 、 Periodontal tissue 、 Proinflammatory cytokine 、 Mechanism (biology) 、 Autoimmunity 、 Medicine 、 Autoantibody 、 Pathogenesis 、 Neutrophil cytoplasmic
摘要: In the past, various models including autoimmunity model have been proposed to explain pathogenesis of periodontal diseases. The aim this review is introduce pathogenic role anti-neutrophil cytoplasmic autoantibodies (ANCAs) in autoimmune diseases and compare these conditions with disease elucidate common mechanisms. Also, a novel based on concept ANCA-associated proposed. This encompasses wide array biochemical mediators that range from direct indirect initiators ANCA production eventual release proinflammatory free radicals, all which implicated tissue destruction past. addition, specific links between typical are discussed. Finally, new paradigm disease-associated includes currently accepted mechanism, namely, genetic-microbial-host interactions.
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joponline.org参考文章(84)
Elena Csernok, Wolfgang L. Gross, Immunogenetic aspects of ANCA-associated vasculitides Karger. ,(1998)
S. W. Cox, B. M. Eley, Cathepsin B/L‐, elastase‐, tryptase‐, trypsin‐ and dipeptidyl peptidase IV‐like activities in gingival crevicular fluid Journal of Clinical Periodontology. ,vol. 19, pp. 333- 339 ,(1992) , 10.1111/J.1600-051X.1992.TB00655.X
Ira B. Larnster, Lyndal G. Holmes, Karen B. Williams Gross, Richard L. Oshrain, D. Walter Cohen, Louis F. Rose, Lourdes M. Peters, Mark R. Pope, The relationship of beta-glucuronidase activity in crevicular fluid to clinical parameters of periodontal disease. Findings from a multicenter study. Journal of Clinical Periodontology. ,vol. 21, pp. 118- 127 ,(1994) , 10.1111/J.1600-051X.1994.TB00289.X
Jian Zhang, Tamás Bárdos, Katalin Mikecz, Alison Finnegan, Tibor T. Glant, Impaired Fas signaling pathway is involved in defective T cell apoptosis in autoimmune murine arthritis. Journal of Immunology. ,vol. 166, pp. 4981- 4986 ,(2001) , 10.4049/JIMMUNOL.166.8.4981
U. Meyer, J. Kleinheinz, M. Gaubitz, M. Schulz, D. Weingart, U. Joos, Orale Manifestationen bei Patienten mit systemischem Lupus erythematodes Mund-, Kiefer- Und Gesichtschirurgie. ,vol. 1, pp. 90- 94 ,(1997) , 10.1007/BF03043521
Yashpal Manchanda, Trilokraj Tejasvi, R Handa, M Ramam, Strawberry gingiva: a distinctive sign in wegener's granulomatosis Journal of the American Academy of Dermatology. ,vol. 49, pp. 335- 337 ,(2003) , 10.1067/S0190-9622(03)00556-5
J. SOBAJIMA, S. OZAKI, F. OSAKADA, H. UESUGI, H. SHIRAKAWA, M. YOSHIDA, K. NAKAO, Novel autoantigens of perinuclear anti-neutrophil cytoplasmic antibodies (P-ANCA) in ulcerative colitis: non-histone chromosomal proteins, HMG1 and HMG2 Clinical and Experimental Immunology. ,vol. 107, pp. 135- 140 ,(1997) , 10.1046/J.1365-2249.1997.D01-907.X
Anders Holmlund, Lennart Hanstrom, Ulf H. Lerner, Bone resorbing activity and cytokine levels in gingival crevicular fluid before and after treatment of periodontal disease Journal of Clinical Periodontology. ,vol. 31, pp. 475- 482 ,(2004) , 10.1111/J.1600-051X.2004.00504.X
E. Parsons, R. A. Seymour, R. I. Macleod, N. Nand, M. K. Ward, Wegener's granulomatosis A distinct gingival lesion Journal of Clinical Periodontology. ,vol. 19, pp. 64- 66 ,(1992) , 10.1111/J.1600-051X.1992.TB01151.X
B. Dibbert, M. Weber, W. H. Nikolaizik, P. Vogt, M. H. Schoni, K. Blaser, H.-U. Simon, Cytokine-mediated Bax deficiency and consequent delayed neutrophil apoptosis: a general mechanism to accumulate effector cells in inflammation. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 96, pp. 13330- 13335 ,(1999) , 10.1073/PNAS.96.23.13330