The effect of aging and acetyl-l-carnitine on the pyruvate transport and oxidation in rat heart mitochondria
作者：
DOI: 10.1016/S0014-5793(99)00809-1
关键词: Phospholipid 、 Cardiolipin 、 Endocrinology 、 Biology 、 Substrate (chemistry) 、 Pyruvate transport 、 Respiration 、 Rat heart 、 Mitochondrion 、 Internal medicine 、 Carnitine
摘要: Abstract The effect of aging and acute treatment with acetyl- l -carnitine on the pyruvate transport oxidation in rat heart mitochondria was studied. activity carrier as well rates pyruvate-supported respiration were both depressed (around 40%) from aged rats, major decrease occurring during second year life. Administration to rats almost completely restored these metabolic functions level young control rats. This not due changes content molecules. mitochondrial cardiolipin, a key phospholipid necessary for substrate transport, markedly reduced (approximately Treatment reversed age-associated decline cardiolipin content. As correlated oxidation, it is suggested that reverses age-related decrement metabolism by restoring normal
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