1 kb of the lactase-phlorizin hydrolase promoter directs post-weaning decline and small intestinal-specific expression in transgenic mice
作者： Jesper T. Troelsen , Anja Mehlum , Jørgen Olsen , Nikolaj Spodsberg , Gert H. Hansen
DOI: 10.1016/0014-5793(94)80519-9
关键词: Lactose intolerance 、 Population 、 Small intestine 、 Gene expression 、 Biology 、 Molecular biology 、 Glycosylceramidase 、 Lactase-phlorizin hydrolase 、 Enterocyte 、 Hydrolase 、 Biophysics 、 Genetics 、 Cell biology 、 Biochemistry 、 Structural biology
摘要: Abstract Adult-type hypolactasia is a genetic condition making approximately one half of the human population intolerant to milk because abdominal symptoms. The cause post-weaning down-regulation intestinal-specific enzyme lactase-phlorizin hydrolase (LPH) reducing intestinal capacity hydrolyze lactose. We here demonstrate that stretch −17 −994 in pig LPH-promoter carries cis-elements which direct small expression and decline linked rabbit β-globin gene. These data LPH mainly due transcriptional down-regulation.
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