Pharmaceuticals that contain polycyclic hydrocarbon scaffolds

摘要: Numerous variations on structural motifs exist within pharmaceutical compounds that have entered the clinic. These amounted over many decades based years of drug development associated with screening natural products and de novo synthetic systems. Caged (or bridged) bicyclic elements offer a variety diverse features, encompassing three-dimensional shape, assorted pharmacokinetic properties. This review highlights approximately 20 all carbon cage containing pharmaceuticals, ranging in structure from bicyclo[2.2.1] through to adamantane, including some top-selling bracket. Although, wide human diseases, illnesses conditions are treated drugs motif, common feature is these lipophilic systems display CNS and/or neurological activity. In addition, an extensive overview history biology each drug, survey methods used construct entities presented. An analysis section compares synthetics discovery, entertains classical caged hydrocarbon potentially missing Lastly, this unprecedented highly pertinent at time when big pharma desperately trying escape flatland drugs.