Effects of fasting and insulin on skeletal development in rats
作者： Richard S. Hannah , Keith L. Moore
关键词: Fasting state 、 Endocrinology 、 Acute hypoglycemia 、 Ossification 、 Axial skeleton 、 Insulin 、 Internal medicine 、 Fetus 、 Medicine 、 Gestation 、 Supernumerary ribs 、 Toxicology 、 Developmental biology 、 Health, Toxicology and Mutagenesis 、 Embryology
摘要: Acute hypoglycemia was produced in pregnant Holtzman rats, by fasting or plus insulin injections. Rats were fasted for 48 hours beginning on days 7, 9, 11 of gestation. Examinations day-21 fetuses showed that greatest susceptibility to the effects occurred during gestation 9 and 10. The noted retarded ossification axial skeleton increased frequency supernumerary ribs, duplicated vertebral centra, asynchronous centra. Insulin administered state no further decrease rate, but ribs centra increased.
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