Rotavirus epidemiology 5-6 years after universal rotavirus vaccination: persistent rotavirus activity in older children and elderly.
作者： Jukka Markkula , Maria Hemming-Harlo , Marjo T. Salminen , Carita Savolainen-Kopra , Jaana Pirhonen
DOI: 10.1080/23744235.2016.1275773
关键词: Medicine 、 Immunization program 、 Pediatrics 、 Vaccination 、 Virology 、 Genotype 、 Rotavirus vaccination 、 Rotavirus 、 Age distribution 、 Epidemiology
摘要: AbstractBackground: Rotavirus (RV) vaccination using RotaTeq® vaccine exclusively was introduced into Finnish National Immunization Program (NIP) in 2009, and soon reached high (≥90%) coverage. Since mid-2013, all stool samples from laboratory diagnosed cases of RV gastroenteritis the entire country have been typed.Methods: 364 positive collected clinical laboratories over a 2-year period were G- P-typed RT-PCR, results confirmed by sequencing. In addition, genome segment encoding for VP6 sequenced to distinguish between wild-type origin (bovine) RVs.Results: winter epidemic seasons 2013–2014 2014–2015 lasted until July each. The age distribution showed two unusual clusters: one children 6–16 years age, too old vaccinated NIP, other elderly 70 age. children, diverse genotypes observed without any obvious predominance. most common ones G1P[8] (30.0%), G2P[4]...
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