Antioxidant behaviour of caffeine: efficient scavenging of hydroxyl radicals.
作者： X. Shi , N.S. Dalal , A.C. Jain
DOI: 10.1016/0278-6915(91)90056-D
关键词: Medicinal chemistry 、 Chemistry 、 Antioxidant 、 Radical 、 Electron paramagnetic resonance 、 Hydroxyl radical 、 Photochemistry 、 Caffeine 、 Chromium 、 Reaction rate constant 、 Spin trapping
摘要: Abstract Considerable controversy exists in the literature regarding toxicity of coffee, including its possible carcinogenic and anticarcinogenic properties. This study reports on reaction 1,3,7-trimethylxanthine (caffeine) with hydroxyl radical (·OH), as investigated by electron spin resonance (ESR) trapping. The ·OH was generated Fenton (Fe 2+ + H 2 O ) well chromium(V) . results show that caffeine effectively scavenges a rate constant ∼ 5.9 × 10 9 m −1 sec is comparable those other efficient scavengers. ESR measurements provide evidence caffeine-derived oxygen-centred formed suggest biochemical basis for understanding reported properties related methylxanthine compounds.
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