Percutaneous absorption of the insecticides fenitrothion and aminocarb in rats and monkeys.
作者： Richard P. Moody , Claire A. Franklin
DOI: 10.1080/15287398709530973
关键词: Anatomy 、 Dermal penetration 、 Fenitrothion 、 Percutaneous absorption 、 Excretion 、 Aminocarb 、 Animal science 、 Biology
摘要: The dermal penetration of 14 C‐ring‐labeled fenitrothion and aminocarb was determined in rats rhesus monkeys. In monkeys, 49 ± 4% (tv2 = h) the 74 25 were absorbed from forehead, while 21 70% 17 37 74% 31 ventral forearm. Monkey forehead 2.3 times 2.0 more permeable than forearm for aminocarb, respectively. rats, 84 72% 20 88 6% middorsal region. These results corrected incomplete excretion by intramuscular injections money, 95 7% 12 h), rat, 69 9% monkey, 14% 8 63 15 h). suggest rapid absorption these pesticides monkeys use animal models measuring is discussed.
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