High dose chemotherapy with stem cell rescue for breast cancer: current status and future directions.

摘要: Dose intensification of particular chemotherapy agents can produce high, complete and overall response rates in women with locally advanced or metastatic breast cancer. High dose stem cell rescue is currently a controversial strategy, not only as component the standard care, but even an investigative field. This review covers preclinical clinical underpinnings high therapy for cancer, including selected phase II trials III reported to date both Proof principle utility this approach requires further maturation data completion ongoing randomized trials. Nonetheless, results are sufficiently compelling support research grants, particularly effort develop multicycle approaches integrate new modalities, such immunotherapy, into framework therapy.