On-line and At-line Liquid Chromatography Nuclear Magnetic Resonance and Related Micro-Nuclear Magnetic Resonance Methods in Natural Product Analysis
作者： Nadine Bohni , Emerson F. Queiroz , Jean-Luc Wolfender
DOI: 10.1002/9780470027318.A9916
关键词: Chromatography 、 Analytical chemistry 、 Nuclear magnetic resonance spectroscopy 、 Nuclear magnetic resonance 、 Mass spectrometry 、 Natural product 、 Line (electrical engineering) 、 Natural Product Research 、 High-performance liquid chromatography 、 Chemistry 、 Metabolite profiling
摘要: Nuclear magnetic resonance spectroscopy (NMR) is essential for the de novo structure identification of natural products. This technique can be directly or indirectly hyphenated to high performance liquid chromatography (HPLC) leading efficient LC-NMR platforms. NMR is, however, a very insensitive detection method compared mass spectrometry and several strategies its hyphenation with HPLC have been developed. includes on-line LC-NMR, SPE-NMR, other at-line approaches involving microflow probes microtubes in combination cryoprobes. All these various technologies their potentials limitations field product research are described. Recent applications complementary methods such as LC-MS biological profiling illustrate utilization.
core.ac.uk
sci-hub.se 参考文章(104)
On-line LC-NMR and related techniques John Wiley & Sons, Ltd. ,(2002) , 10.1002/0470854820
Sang Min Kim, Suk Woo Kang, Je-Seung Jeon, Yu-Jin Jung, Chul Young Kim, Cheol Ho Pan, Byung-Hun Um, Rapid identification and evaluation of antioxidant compounds from extracts of Petasites japonicus by hyphenated-HPLC techniques Biomedical Chromatography. ,vol. 26, pp. 199- 207 ,(2012) , 10.1002/BMC.1646
Justin J.J. van der Hooft, Velitchka Mihaleva, Ric C.H. de Vos, Raoul J. Bino, Jacques Vervoort, A strategy for fast structural elucidation of metabolites in small volume plant extracts using automated MS-guided LC-MS-SPE-NMR. Magnetic Resonance in Chemistry. ,vol. 49, ,(2011) , 10.1002/MRC.2833
Maja Lambert, Dan Stærk, Steen Honoré Hansen, Majid Sairafianpour, Jerzy W Jaroszewski, Rapid Extract Dereplication Using HPLC-SPE-NMR: Analysis of Isoflavonoids from Smirnowia iranica Journal of Natural Products. ,vol. 68, pp. 1500- 1509 ,(2005) , 10.1021/NP0502037
Kenneth T Johansen, Sarah J Ebild, S Brøgger Christensen, Markus Godejohann, Jerzy W Jaroszewski, None, Alkaloid analysis by high-performance liquid chromatography-solid phase extraction-nuclear magnetic resonance: New strategies going beyond the standard Journal of Chromatography A. ,vol. 1270, pp. 171- 177 ,(2012) , 10.1016/J.CHROMA.2012.10.072
Chris M. Cooper, Noel W. Davies, Cherie A. Motti, Robert C. Menary, Glycosidic conjugates of C13 norisoprenoids, monoterpenoids, and cucurbates in Boronia megastigma (Nees). Journal of Agricultural and Food Chemistry. ,vol. 59, pp. 2610- 2617 ,(2011) , 10.1021/JF104051T
Wolfgang Kreiss, Rita Fröde, Volker Möhrle, Günther Eberz, Chromatography-bioluminescence coupling reveals surprising bioactivity of inthomycin A. Analytical and Bioanalytical Chemistry. ,vol. 398, pp. 2081- 2088 ,(2010) , 10.1007/S00216-010-4086-9
Yiqing Lin, Susan Schiavo, Jimmy Orjala, Paul Vouros, Roger Kautz, Microscale LC-MS-NMR platform applied to the identification of active cyanobacterial metabolites. Analytical Chemistry. ,vol. 80, pp. 8045- 8054 ,(2008) , 10.1021/AC801049K
Doralyn S. Dalisay, Brandon I. Morinaka, Colin K. Skepper, Tadeusz F. Molinski, A tetrachloro polyketide hexahydro-1H-isoindolone, muironolide A, from the marine sponge Phorbas sp. natural products at the nanomole scale. Journal of the American Chemical Society. ,vol. 131, pp. 7552- 7553 ,(2009) , 10.1021/JA9024929
Steven Ray Wilson, Helle Malerød, Dirk Petersen, Nebojsa Simic, Maria-Magdalena Bobu, Frode Rise, Elsa Lundanes, Tyge Greibrokk, Controlling LC–SPE–NMR systems Journal of Separation Science. ,vol. 29, pp. 582- 589 ,(2006) , 10.1002/JSSC.200500359