Potentiation by vasopressin of corticotropin release induced by corticotropin-releasing factor.

作者： F.E. YATES , S.M. RUSSELL , M.F. DALLMAN , G.A. HEDGE , S.M. McCANN

关键词: Corticotropin-releasing hormone 、 Anterior pituitary 、 Morphine 、 Dexamethasone 、 Diabetes insipidus 、 Internal medicine 、 Endocrinology 、 Vasopressin 、 Chemistry 、 Oxytocin 、 Adrenocorticotropic hormone

摘要: To determine whether vasopressin affects the sensitivity of anterior pituitary to corticotropin-releasing factor, was administered intravenously in doses subthreshold with respect ACTH release rats pretreated dexamethasone (dex), Nembutal (Nem), and, sometimes, also morphine (morph). Crude ovine CRF given immediately following vasopressin. The adrenocortical response increased at least 100% by prior administration When 1/20 intravenous dose placed into both lobes it again failed itself, but 2.5 times intravenously. This potentiation CRF-induced adenohypophysis not observed if one lobe only pituitary. In dex +Nem same as those + Nem+morph. Ox...