Deficiency of 8-hydroxyguanine dna endonuclease activity and accumulation of the 8-hydroxyguanine in mutator mutant (mutM) of Escherichia coli
作者： Tadayoshi Bessho , Keizo Tano , Hiroshi Kasai , Susumu Nishimura
DOI: 10.1016/0006-291X(92)92395-E
关键词: Mutation 、 Enzyme 、 Strain (chemistry) 、 DNA 、 Mutant 、 DNA-formamidopyrimidine glycosylase 、 Endonuclease 、 Molecular biology 、 Escherichia coli 、 Biology 、 Biochemistry
摘要: In this report, we have characterized mutM mutant with respect to its ability repair 8-hydroxyguanine (oh8Gua) in DNA. The oh8Gua DNA endonuclease activity strain was minimal as compared that the wild-type cells. presence of 6-fold corresponding a characteristically higher frequency G.C-->T.A transversions strain. These results suggest mutator phenotype is at least partially due spontaneous accumulation resulting from greatly reduced activity.
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