The Improved Cargo Loading and Physical Stability of Ibuprofen Orodispersible Film: Molecular Mechanism of Ion-Pair Complexes on Drug-Polymer Miscibility
作者： Jie Liu , Jian Guan , Xiaocao Wan , Rui Shang , Xinyu Shi
DOI: 10.1016/J.XPHS.2019.12.005
关键词: Hydrogen bond 、 Miscibility 、 Chemical engineering 、 Sublimation (phase transition) 、 Polymer 、 Solubility 、 Counterion 、 Dissolution testing 、 Thin film 、 Materials science 、 Pharmaceutical Science
摘要: Abstract High drug cargo loading in polymer and physical stability was essential for the development of orodispersible films (ODFs) because small amount excipients used a thin film. The present study aimed to investigate mechanism ion-pair strategy improving ODFs. results showed that ion pair, especially ibuprofen-ethanolamine, improved solubility up 60% (w/w) by 30% than pure ibuprofen In addition, dissolution rate increased over 2 times. high loading, derived from drug-polymer miscibility introduced formation complex. Investigations standpoint physicochemical properties, intermolecular interaction, mobility indicated modulation complexes ODFs at molecular level. amino group and −OH counter exhibited strong hydrogen bond forming ability, which bilateral interaction with both polymer, delayed onset temperature sublimation decreased mobility. Therefore, technology is promising drug-excipient stability.
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