Haploidentical Transplants: Nonmalignant Diseases in Adults

摘要: Haploidentical transplantation is becoming a common practice in recent times particularly after the introduction of post-transplant cyclophosphamide by Johns Hopkins group (Luznik et al. Biol Blood Marrow Transplant 14(6):641–650, 2008; Bacigalupo Adv Hematol 2016:7802967, 2016). In past, excessive morbidity and mortality caused HLA-mismatched transplant made this intervention very high risk for treatment-related mortality, but nowadays it appears that outcomes are similar to those HLA-matched transplants, i.e., HLA-matched, related, or unrelated (Ciurea 126(8):1033–1040, 2015; Kanate 127(7):938–947, 2016; Ghosh J Clin Oncol 34(26):3141–3149, fact, they appear compare well with other alternative donors such as cord transplants (Brunstein 118(2):282–288, 2011). There many potential advantages using haploidentical when needed. Given toxicity seen not different compared types allogeneic approaches, its use hereditary nonmalignant disorders seems logical exploration. chapter, results approach patients will be reviewed.