IgG subclasses of antineutrophil cytoplasm autoantibodies (ANCA)

摘要: Sera that had been positive in routine ELISA for ANCA were studied retrospectively the IgG subclass distribution of these autoantibodies. An previously developed measurement sub classes anti-GBM antibodies was modified this purpose. Of a total 247 sera, 114 found to be at least one assays subclasses anti proteinase 3, 72 patients men and 42 women, giving ratio 1.8. Also 134 sera antimyeloperoxidase (MPO), with male/female 0 97. The seem consist mainly IgGI IgG4 Among anti-MPO group, IgG2 is relatively common IgG3 scarce. Contrasting this, antiproteinase 3 group. In group high titres are rare. Twelve both autoantigens. Clinical data 44 patients. Prognosis old poor. Patients inactive disease often only assay, while active two or more (P<001). (Less)