The Maintenance of Telomere Length in CD28+ T Cells During T Lymphocyte Stimulation.

摘要: Telomerase activity is not readily detected in resting human T lymphocytes, however upon antigen presentation, telomerase transiently upregulated. Presently, it known if activation necessary for the proliferation of cells or maintenance telomere lengths. In this study, we found that required short- term and telomeres progressively shorten a heterogeneous population cells, even detected. By measuring at single-cell level using quantitative ddPCR techniques (ddTRAP) by monitoring changes shortest with more sensitive length measurement assays, show only subset CD28+ T-cells have robust stimulation are capable maintaining their lengths during induced proliferation. The study T-cell may lead to better understanding on how regulated functions immune cells.