Coexpression of biological key modulators in primary colorectal carcinomas and related metastatic sites: implications for treatment with cetuximab

摘要: Abstract Background Recent studies suggested substantial differences between primary tumors and metastases for EGFR expression in colorectal cancer (CRC). The aim of the study was to correlate a panel molecular markers CRC samples metastases. Methods Expressions EGFR, pEGFR, VEGF, pVEGF, PTEN, pAKT p21 were analyzed 28 32 liver by immunohistochemistry performed on formalin-fixed, paraffin-embedded sections from 46 patients. profiles evaluated tissue micro-array. correlation tumor metastasis biomarker expressions tested. Results Among 60 samples, 25% positive, 38% pEGFR 38%were VEGF 48% pVEGF 70% positive 51%were positive. PTEN deleted 39% cases absence found 49% cases. Asignificant observed (p = 0.037) (p = 0.0002) status. In patients treated with cetuximab-based therapy (n = 18), appeared as significant predictive factor response (p = 0.036). Conclusion Biomarkers status may change metastatic sites CRC, potential implications identification who are likely respond anti-EGFR treatment.