Identification of metabolic engineering targets for the enhancement of 1,4-butanediol production in recombinant E. coli using large-scale kinetic models
作者： Stefano Andreozzi , Anirikh Chakrabarti , Keng Cher Soh , Anthony Burgard , Tae Hoon Yang
DOI: 10.1016/J.YMBEN.2016.01.009
关键词: Escherichia coli 、 Metabolic pathway 、 Computational biology 、 Biochemistry 、 Chemistry 、 Metabolic engineering 、 Citric acid cycle 、 Enzyme 、 Population 、 Flux balance analysis 、 Scale (chemistry)
摘要: … producing 1,4-butanediol (BDO) and to identify potential strategies for improved production of … that primarily control the fluxes leading to BDO production are part of central glycolysis, the …
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sci-hub.se 参考文章(64)
Brian Thompson, Michael Machas, David R Nielsen, Creating pathways towards aromatic building blocks and fine chemicals Current Opinion in Biotechnology. ,vol. 36, pp. 1- 7 ,(2015) , 10.1016/J.COPBIO.2015.07.004
Reinhart Heinrich, Stefan Schuster, The Regulation of Cellular Systems ,(1996)
F Mat-Jan, K Y Alam, D P Clark, Mutants of Escherichia coli deficient in the fermentative lactate dehydrogenase. Journal of Bacteriology. ,vol. 171, pp. 342- 348 ,(1989) , 10.1128/JB.171.1.342-348.1989
Wolfram Liebermeister, Edda Klipp, Bringing metabolic networks to life: convenience rate law and thermodynamic constraints. Theoretical Biology and Medical Modelling. ,vol. 3, pp. 41- 41 ,(2006) , 10.1186/1742-4682-3-41
P M Silverman, S Rother, H Gaudin, Arc and Sfr functions of the Escherichia coli K-12 arcA gene product are genetically and physiologically separable. Journal of Bacteriology. ,vol. 173, pp. 5648- 5652 ,(1991) , 10.1128/JB.173.18.5648-5652.1991
Ljubisa Miskovic, Milenko Tokic, Georgios Fengos, Vassily Hatzimanikatis, Rites of passage: requirements and standards for building kinetic models of metabolic phenotypes Current Opinion in Biotechnology. ,vol. 36, pp. 146- 153 ,(2015) , 10.1016/J.COPBIO.2015.08.019
Mark J. Burk, Robin E. Osterhout, Jun Sun, Anthony P. Burgard, Microorganisms for the production of 1,4-butanediol ,(2009)
Bas Teusink, Jutta Passarge, Corinne A. Reijenga, Eugenia Esgalhado, Coen C. van der Weijden, Mike Schepper, Michael C. Walsh, Barbara M. Bakker, Karel van Dam, Hans V. Westerhoff, Jacky L. Snoep, Can yeast glycolysis be understood in terms of in vitro kinetics of the constituent enzymes? Testing biochemistry. FEBS Journal. ,vol. 267, pp. 5313- 5329 ,(2000) , 10.1046/J.1432-1327.2000.01527.X
L Stols, M I Donnelly, Production of succinic acid through overexpression of NAD(+)-dependent malic enzyme in an Escherichia coli mutant. Applied and Environmental Microbiology. ,vol. 63, pp. 2695- 2701 ,(1997) , 10.1128/AEM.63.7.2695-2701.1997
Meric Ataman, Vassily Hatzimanikatis, Heading in the right direction: thermodynamics-based network analysis and pathway engineering. Current Opinion in Biotechnology. ,vol. 36, pp. 176- 182 ,(2015) , 10.1016/J.COPBIO.2015.08.021