Urinary 5-HIAA excretion is not increased in patients with head and neck paragangliomas.
作者： Leonie T. Van Hulsteijn , Nicolette Van Duinen , Johannes A. Romijn , Johannes W.A. Smit , Eleonora P.M. Corssmit
关键词: Internal medicine 、 Epinephrine 、 Normetanephrine 、 Endocrinology 、 Reference range 、 Urinary system 、 Urine 、 Metanephrine 、 Hormone 、 Medicine 、 Excretion
摘要: Background: Case reports have documented carcinoid-like features in head and neck paragangliomas (HNPGLs), which, addition to catecholamine storing granules, may also contain granules with serotonin. Serotonin is metabolized 5-hydroxyindoleacetic acid (5-HIAA). Aim: To assess the urinary excretion rates of 5-HIAA catecholamines HNPGL patients.Methods: In 114 consecutive patients, normetanephrine, metanephrine, norepinephrine, epinephrine, VMA, dopamine, 3-methoxytyramine were measured two 24-hour samples. Increased defined as an increase average hormone rate 2 urine samples above reference range. all patients excess, intrathoracic abdominal excluded by 123I-MIBG scintigraphy, MRI and/or CT. Genetic screening for mutations genes succinate dehydrogenase (SDH) family was performed. Results: Mean 14+/-9 mumol/24 hours (reference range 10-44 hours). Urinary slightly increased only 1 patient (48 None 50 (44%) their metabolites had elevated excretion.Conclusion: within normal almost patients. Therefore, this parameter has no clinical relevance routine assessment
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