Impact of PCV7/PCV13 introduction on community-acquired alveolar pneumonia in children <5 years

作者: David Greenberg , Noga Givon-Lavi , Shalom Ben-Shimol , Jacob Bar Ziv , Ron Dagan

DOI: 10.1016/J.VACCINE.2015.06.062

关键词: PediatricsPneumococcal conjugate vaccineMedicineWorld healthPneumoniaPopulationCommunity-acquired pneumoniaCurrent analysisBacterial disease

摘要: Abstract Background Alveolar community-acquired pneumonia (A-CAP) is mostly considered a bacterial disease, mainly pneumococcal. This study was conducted to document the impact of sequential 7-valent and 13-valent pneumococcal conjugate vaccines (PCV7; PCV13) on emergency room hospitalization for A-CAP among children Methods an ongoing prospective population-based in southern Israel. The current analysis spans over period July 2002 through June 2013. defined using World Health Organization (WHO)’s criteria radiologically-confirmed pneumonia. PCV7 introduced Israel 2009 gradually replaced by PCV13 November 2010. Pneumococcal vaccine (PCV) calculated comparing incidences during 3 pre-defined periods: pre-PCV (2002–2008), (2010–2011) (2012–2013). Results Overall, 10,142 episodes occurred. annual (per 1,000 inhabitants) vs. 32% hospitalized period). While 12–23 months significant decline observed periods, declines rates were only Conclusions A moderate hospital visits

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