Borderline-Tumor des Ovars
作者： D. O. Bauerschlag , I. Meinhold , C. Schem , C. Mundhenke , W. Jonat
DOI: 10.1007/S00129-006-1837-Y
关键词: Borderline tumor 、 Gynecology 、 Medicine
摘要: Der Borderline-Tumor des Ovars tritt im Gegensatz zum invasiven Ovarialkarzinom 10 Jahre fruher auf und zeigt eine exzellente Zehnjahresuberlebensrate. Traditionell wird der Borderline- oder LMP-Tumor als pramaligne Erkrankung gesehen. Inwieweit sich das Stufenmodell Karzinogenese LMP-/Borderline-Tumoren anwenden lasst, ist noch nicht abschliesend geklart. Molekulargenetische Hinweise deuten darauf hin, dass gut differenzierte Ovarialkarzinome stufenweise aus dem Zystadenom entstehen. Dagegen scheint es beim masig gering differenzierten um De-novo-Entstehung zu handeln. Therapeutisch steht die zytoreduktive Chirurgie klar Vordergrund. Histopathologisch ergeben Subklassifizierungen – mikropapillares Wachstum invasive Implantate von LMP-Tumoren, mit einem aggressiveren biologischen Verhalten vergesellschaftet sind. Insgesamt Tumorbiologie Ovarialtumors niedrigmaligner Potenz geklart somit Gegenstand aktuellen Forschungsgeschehens.
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