The preponderance of P450s in the Mycobacterium tuberculosis genome
作者： Kirsty J. McLean , Daniel Clift , D. Geraint Lewis , Muna Sabri , Philip R. Balding
DOI: 10.1016/J.TIM.2006.03.002
关键词: Genetics 、 Cytochrome P450 、 DNA 、 Mycobacterium tuberculosis 、 Microbiology 、 Human pathogen 、 Function (biology) 、 Biology 、 Enzyme 、 Sequence analysis 、 Genome
摘要: The genome of Mycobacterium tuberculosis (Mtb) encodes 20 different cytochrome P450 enzymes (P450s). P450s are mono-oxygenases, which historically considered to facilitate prokaryotic usage unusual carbon sources. However, their preponderance in Mtb strongly indicates crucial physiological functions, as does the fact that polycyclic azoles (known inhibitors) have potent anti-mycobacterial effects. Recent structural and enzyme characterization data reveal novel features for at least two (CYP121 CYP51). Genome analysis, knockout studies comparisons signify important roles cell biology pathogenesis various redox partner Mtb. Elucidation structure, function metabolic will be essential targeting an 'Achilles heel' this major human pathogen.
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