High-resolution melting assay for genotyping of IFNL4-associated dinucleotide variant rs368234815
作者： E. Galmozzi , F. Facchetti , R. Perbellini , A. Aghemo
关键词: Real-time polymerase chain reaction 、 Hepatitis C virus 、 High Resolution Melt 、 Genotyping 、 Virology 、 Biology 、 Chronic hepatitis 、 Genetic marker 、 Molecular biology
摘要: Interferon-λ4-related dinucleotide variant rs368234815 TT/-G is strongly linked with rs12979860 polymorphism, the most important genetic marker connected to treatment-induced hepatitis C virus clearance. Due additional baseline information that polymorphism could provide for management of chronic C, we developed and validated a high-resolution melting genotyping assay using 193 patients C.
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