Influence of Bone Marrow Microenvironment on Leukemic Stem Cells: Breaking Up an Intimate Relationship.
作者： Puneet Agarwal , Ravi Bhatia
DOI: 10.1016/BS.ACR.2015.04.007
关键词: Immunology 、 Signal transduction 、 Stem cell 、 Conventional chemotherapy 、 Bone marrow 、 Leukemia Stem Cell 、 Crosstalk (biology) 、 Cancer research 、 Haematopoiesis 、 DISEASE RELAPSE 、 Biology
摘要: The bone marrow microenvironment (BMM) plays a critical role in hematopoietic stem cells (HSCs) maintenance and regulation. There is increasing interest the of BMM promoting leukemia cell (LSC) maintenance, resistance to conventional chemotherapy targeted therapies, ultimately disease relapse. Recent studies have enhanced our understanding how regulates quiescence, self-renewal, differentiation LSC. In this comprehensive review, we discuss recent advances crosstalk between LSC, signaling pathways underlying these interactions. We also potential approaches exploit observations create novel strategies for targeting therapy-resistant LSC achieve relapse-free survival leukemic patients.
sci-hub.se 参考文章(133)
Irving L Weissman, Stem cells: units of development, units of regeneration, and units in evolution. Cell. ,vol. 100, pp. 157- 168 ,(2000) , 10.1016/S0092-8674(00)81692-X
Andrew G. Evans, Laura M. Calvi, Notch signaling in the malignant bone marrow microenvironment: implications for a niche-based model of oncogenesis. Annals of the New York Academy of Sciences. ,vol. 1335, pp. 63- 77 ,(2015) , 10.1111/NYAS.12562
BI Lord, NG Testa, JH Hendry, The relative spatial distributions of CFUs and CFUc in the normal mouse femur Blood. ,vol. 46, pp. 65- 72 ,(1975) , 10.1182/BLOOD.V46.1.65.65
Raymond Schofield, The relationship between the spleen colony-forming cell and the haemopoietic stem cell Blood cells. ,vol. 4, pp. 7- 25 ,(1978)
Christina Schreck, Franziska Bock, Sandra Grziwok, Robert A.J. Oostendorp, Rouzanna Istvánffy, Regulation of hematopoiesis by activators and inhibitors of Wnt signaling from the niche. Annals of the New York Academy of Sciences. ,vol. 1310, pp. 32- 43 ,(2014) , 10.1111/NYAS.12384
Eric Cordeiro-Spinetti, Russell S. Taichman, Alex Balduino, The bone marrow endosteal niche: how far from the surface? Journal of Cellular Biochemistry. ,vol. 116, pp. 6- 11 ,(2015) , 10.1002/JCB.24952
M. Y. Gordon, C. R. Dowding, G. P. Riley, J. M. Goldman, M. F. Greaves, Altered adhesive interactions with marrow stroma of haematopoietic progenitor cells in chronic myeloid leukaemia. Nature. ,vol. 328, pp. 342- 344 ,(1987) , 10.1038/328342A0
Marieke Alida Gertruda Essers, Andreas Trumpp, None, Targeting leukemic stem cells by breaking their dormancy Molecular Oncology. ,vol. 4, pp. 443- 450 ,(2010) , 10.1016/J.MOLONC.2010.06.001
Daruka Mahadevan, Alan F. List, Targeting the Multidrug Resistance-1 Transporter in AML: Molecular Regulation and Therapeutic Strategies Blood. ,vol. 104, pp. 1940- 1951 ,(2004) , 10.1182/BLOOD-2003-07-2490
Maria Krevvata, Barbara C. Silva, John S. Manavalan, Marta Galan-Diez, Aruna Kode, Brya Grace Matthews, David Park, Chiyuan A. Zhang, Naomi Galili, Thomas L. Nickolas, David W. Dempster, William Dougall, Julie Teruya-Feldstein, Aris N. Economides, Ivo Kalajzic, Azra Raza, Ellin Berman, Siddhartha Mukherjee, Govind Bhagat, Stavroula Kousteni, Inhibition of leukemia cell engraftment and disease progression in mice by osteoblasts Blood. ,vol. 124, pp. 2834- 2846 ,(2014) , 10.1182/BLOOD-2013-07-517219