Liver transplantation in pediatric patients: Twenty years of experience at the University of Wisconsin

摘要: :  Developments in surgical technique, immunosuppression, organ procurement and preservation, patient selection criteria have resulted improved long-term graft survival after pediatric liver transplantation. In this study, we examined the results of 196 transplants performed 155 patients at University Wisconsin Children’s Hospital. Patients were divided into two groups according to age time transplant. Infants under 12 months comprised Group 1 (n = 74) children from one 18 yr 2 (n = 122). Outcomes for whole, reduced-size, split transplantation compared infants children. Biliary atresia was most common indication both groups. underwent 128 whole size, 50 reduced 18 transplants. Forty-one retransplantations 14 (18.9%) 27 (22.1%). One hundred eleven (56.6%) had or more rejection episode [37 (50.0%) 74 (60.6%)]. Thirty-nine (19.8%) developed CMV infections, 42 (21.4%) EBV PTLD (six eight children). Thirty-six (18.3%) HAT. Seven (4.5%) malignancy (one infant six Out patients, 33 (21.3%) died during study period. The etiology mortality included central nervous system pathology (n = 7; 4.5%), sepsis (n = 6; 3.8%), cardiac causes 3.8%). One-, five-, 10-yr actuarial 86, 79, 74% 90, 83 80% Graft one, five, 10 yr 77, 73 71% 88, 81 78% children, respectively. Despite its technical challenges, outcomes with end-stage disease are excellent result significant survival.