Reply: Heterozygous PINK1 p.G411S in rapid eye movement sleep behaviour disorder
作者： Andreas Puschmann , Fabienne C Fiesel , Thomas R Caulfield , Roman Hudec , Maya Ando
DOI: 10.1093/BRAIN/AWX077
关键词: Internal medicine 、 Neurology 、 Neuroscience 、 PINK1 、 REM sleep behavior disorder 、 Odds ratio 、 Statistical significance 、 Gastroenterology 、 Cohort 、 Disease 、 Psychology 、 Rapid eye movement sleep behaviour disorder
摘要: We read with great interest that Gan-Or et al. (2017) have observed an association (albeit not reaching statistical significance) of the heterozygous PINK1 p.G411S mutation and rapid eye movement sleep behaviour disorder [RBD; effect size odds ratio (OR) 2.49] in their multicentre cohort 350 RBD patients 869 controls subjects (Gan-Or al., 2017). Given strong correlation Parkinson’s disease, we interpret this as further support for our observation on 9142 individuals showing confers a marked increase disease risk = 2.89, P 0.027 (Puschmann
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