Acute promyelocytic leukemia in 57 previously untreated patients.

摘要: Fifty-seven patients in initial phase of acute promyelocytic leukemia (APL) were treated the same department with heparin infusion, platelet transfusions, and two related induction regimens both including cytosine arabinoside daunorubicin. Clinical biological findings at presentation studied. The complete remission (CR) rate was 53%. Twenty-seven (47%) died during course disease, either before day 5 (early death [ED], n = 7) or after (death aplasia [DA], 20). Most ED due to intracerebral hemorrhage (6/7), especially when large hemorrhages had been seen on fundus oculi examination. DA multivisceral failure (9/20). No correlation found between disseminated intravascular coagulation (DIC) death. However, worsening parameters therapy, without DIC, significantly increased occurrence renal respiratory which particularly frequent first month. median duration survival short (3.5 months) CR (11 similar that other myeloid leukemias regimens. possible causes high mortality observed courses APL benefit a more graduate chemotherapy are discussed.