Choline acetyltransferase activity at different ages in brain of Ts65Dn mice, an animal model for Down's syndrome and related neurodegenerative diseases

摘要: Ts65Dn mice, trisomic for a portion of chromosome 16 segmentally homologous to human 21, are an animal model Down's syndrome and related neurodegenerative diseases, such as dementia the Alzheimer type. In these cognitive deficits alterations in number basal forebrain cholinergic neurons have been described. We measured mice catalytic activity marker, choline acetyltransferase (ChAT), well acetylcholine-degrading enzyme acetylcholinesterase (AChE), hippocampus cortical targets neurons. aged 10 months, ChAT was significantly higher compared 2N animals, hippocampus, olfactory bulb, cortex, pre-frontal but not other neocortical regions. At 19 months age, on hand, no differences were found. Thus, areas seem recapitulate those recently described patients scored cases mild impairment or Alzheimer's disease. Other neurochemical markers putatively associated with disease progression, implicating astrocytic hyperactivity overproduction amyloid precursor protein family, preferentially found altered some brain regions at oldest age examined (19 months).