Down-regulation of hepatic CYP3A in chronic renal insufficiency
作者： Bhaskar Rege , Richard Krieg , Ning Gao , Mohamadi A. Sarkar
关键词: Endocrinology 、 Biology 、 Kidney disease 、 Cyp450 enzymes 、 Cytochrome P450 、 Chronic renal insufficiency 、 Downregulation and upregulation 、 CYP3A 、 Drug metabolism 、 Internal medicine 、 Gastroenterology 、 Pharmacokinetics
摘要: Purpose. The objective of this study was to investigate the mechanisms underlying decrease in hepatic clearance some drugs metabolized by CYP450 enzymes chronic renal insufficiency (CRI).
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