Collision-induced fragmentation of (M + H)+ ions of peptides. Side chain specific sequence ions
作者： Richard S. Johnson , Stephen A. Martin , Klaus Biemann
DOI: 10.1016/0168-1176(88)80060-0
关键词: Chemistry 、 Mass spectrometry 、 Crystallography 、 Analytical chemistry 、 Side chain 、 Protonation 、 Fast atom bombardment 、 Collision-induced dissociation 、 Ionization 、 Ion 、 Fragmentation (mass spectrometry)
摘要: Abstract The collision (10 keV)-induced decomposition (CID) of (M + H)+ ions peptides generated by fast atom bombardment ionization has been studied in a tandem mass spectrometer consisting two consecutive double-focussing analyzers. Two novel fragmentation processes are described; one (termed dn) leads to the formation N-terminal that permit differentiation leucine isoleucine; other new set C-terminal vn) and is related structure amino acid representing N-terminus fragment. mechanisms supported B2/E B/E scans, which define precursor product ions. These fragmentations under CID conditions kilovolt energies seem involve at site remote from charge. undergo protonation degree positive charge fixed site.
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