Psychoactive Medications and Risk of Delirium in Hospitalized Cancer Patients
作者： Jean-David Gaudreau , Pierre Gagnon , François Harel , Marc-André Roy , Annie Tremblay
关键词: Psychiatry 、 Risk assessment 、 Risk factor 、 Hazard ratio 、 Delirium 、 Internal medicine 、 Cohort study 、 Proportional hazards model 、 Organic mental disorders 、 Medicine 、 Epidemiology
摘要: Purpose Psychoactive medications are biologically plausible and potentially modifiable risk factors of delirium. To date, however, research findings inconsistent regarding their association with The between exposure to anticholinergics, benzodiazepines, corticosteroids, opioids the delirium was studied. Patients Methods A total 261 hospitalized cancer patients were followed up repeated assessments by using Nursing Delirium Screening Scale for 4 weeks incident Detailed psychoactive documented daily. Strengths expressed as hazard ratios (HRs) in univariate multivariate analyses Cox regression models. All medication variables coded time-dependent covariates. Whenever possible, computed cumulative daily doses equivalents; dichotomous cutoffs determined. Results During follow-up (mean, 8.6 days), 43 became delirio...
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