Glioma Proteomics: Methods and Current Perspective

摘要: The Glioblastoma (WHO grade IV astrocytoma) is the most common and malignant primary adult brain cancer. present standard treatment appears to be maximal safe resection of tumor followed by irradiation temozolomide adjuvant chemotherapy. Despite advances in modalities, median survival very poor. In addition, recent molecular genetic profiling studies using various genomic technologies have identified several markers unique signatures as prognostic predictive factors GBM. However, none them are translated into clinics. Thus with a requirement additional more potent markers, proteomics promising particular for reasons like transcript levels does not correlate protein due variety differences translation efficiency, stability miRNA regulation. conventional methods 2-dimensional gel electrophoresis been use nearly last few decades. our ability identify proteins through mass spectrometry created renewed interest proteomics. It anticipated that technological advancements happening free high throughput quantitative going revolutionize biomarker discovery classification, prognosis, monitoring response novel targets better besides understanding glioma biology.