Non-enzymatic modification of proteins by steroids: Pathological implications for autoimmunity and glucocorticoid toxicity

摘要: Certain steroids can react with proteins to form stable, covalent addition products. 16α-hydroxyestrone and the glucocorticoids, for example, contain ketol moieties which permit them non-enzymatically by forming Schiffbase rearrangement products lysine residues. The oral contraceptive agent, 17α-ethinylestradiol, add after being enzymatically activated microsomal oxidation. Elevated plasma levels of these result in an increased amount protein modification vivo. Recent investigations have linked occurrence steroid-modified pathological sequelae associated high steroid levels.