T-cell expression of AhR inhibits the maintenance of pTreg cells in the gastrointestinal tract in acute GVHD.
作者： Trisha A. Dant , Kaifeng L. Lin , Danny W. Bruce , Stephanie A. Montgomery , Oleg V. Kolupaev
DOI: 10.1182/BLOOD-2016-08-734244
关键词: Immunology 、 Immune system 、 In vitro 、 Receptor 、 Cell growth 、 Aryl hydrocarbon receptor 、 Pathogenesis 、 Biology 、 Transplantation 、 T cell
摘要: The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that affects the function and development of immune cells. Here, we show recipient mice receiving AhR-/- T cells have improved survival decreased acute graft-versus-host disease (aGVHD) in 2 different murine allogeneic bone marrow transplant (BMT) models. We also CD4+ lacking AhR demonstrate reduced accumulation secondary lymphoid tissue because low levels proliferation 4 days after BMT. Additionally, found significant increase quantity peripherally induced regulatory donor (pTreg) colon recipients transplanted with 14 transplant. Blockade using clinically available antagonist greatly enhanced vitro generation inducible Treg (iTreg) from naive human identified as novel target on critical to pathogenesis aGVHD.
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