Phenothiazines: an alternative to conventional therapy for the initial management of suspected multidrug resistant tuberculosis. A call for studies

摘要: Increased frequency of multidrug resistant strains Mycobacterium tuberculosis results from inappropriate treatment and lack patient compliance. The Center for Disease Control/American Thoracic Society (CDC/ATS) guidelines issued the management newly diagnosed cases (TB) will not be totally effective regardless adherence to cooperation. long interim period between diagnosis TB confirmation antibiotic susceptibility contributes infection rate. Consequently, use an adjuvant that is known inhibit all encountered M. may helpful until known. Phenothiazines such as chlorpromazine, methdilazine thioridazine are against in vitro vivo. It recommended studies designed conducted purpose managing new emanate areas harbour tuberculosis, with phenothiazines adjuvants regimen by CDC/ATS defined. Because normal maximum obtaining conventional less than 7 or 8 weeks, probability serious side effects a phenothiazine remote.