Development of efficient processes for multi-gram scale and divergent preparation of fluorous-Fmoc reagents
作者： Yuya Sugiyama , Natsuki Endo , Kazuki Ishihara , Yuki Kobayashi , Hiromi Hamamoto
DOI: 10.1016/J.TET.2015.05.083
关键词: Chemistry 、 Reagent 、 Organic chemistry 、 Fluorine 、 Gram 、 Combinatorial chemistry 、 Molecule 、 Heck reaction
摘要: Abstract An optimized, multi-gram scale synthesis of fluorous-Fmoc reagents is described. Fmoc bearing C3F7, C4F9, and C6F13 chains were prepared on (ca. 1.0–7.0 g) in eight steps with overall yields 73%, 60%, 90%, respectively. The order addition the fluorous alkenes a one-pot double tagging Heck reaction was also investigated to conduct an encoded mixture f-Fmoc reagents. target could be effectively separated based fluorine content molecules.
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