The use of magnetite nanoparticles for implant-assisted magnetic drug targeting in thrombolytic therapy.

作者: Henrik Kempe , Maria Kempe

DOI: 10.1016/J.BIOMATERIALS.2010.07.107

关键词: NanoparticleTetraethyl orthosilicatePolyethylene glycolDrug deliveryMaterials scienceMagnetic nanoparticlesImmobilized enzymeIn vivoBiomedical engineeringTargeted drug delivery

摘要: … The nanoparticles were silanized with tetraethyl orthosilicate in the presence of triethylene glycol and/or polyethylene glycol. The surface coated magnetite nanoparticles were activated …

参考文章(66)
K.F. O'Driscoll, [12] Techniques of enzyme entrapment in gels Methods in Enzymology. ,vol. 44, pp. 169- 183 ,(1976) , 10.1016/S0076-6879(76)44014-4
William H. Scouten, [2] A survey of enzyme coupling techniques Methods in Enzymology. ,vol. 135, pp. 30- 65 ,(1987) , 10.1016/0076-6879(87)35063-3
Paul A. Srere, Kosaku Uyeda, [2] Functional groups on enzymes suitable for binding to matrices Methods in Enzymology. ,vol. 44, pp. 11- 19 ,(1976) , 10.1016/S0076-6879(76)44004-1
Kurt Nilsson, Klaus Mosbach, [3] Tresyl chloride-activated supports for enzyme immobilization Methods in Enzymology. ,vol. 135, pp. 65- 78 ,(1987) , 10.1016/0076-6879(87)35064-5
Andreas Stephan Lübbe, Friedhelm Herrmann, Peter Reichardt, Folke Schriever, Dieter Huhn, Kurt Possinger, Bernd Dörken, Winfried Huhnt, Arne-Jürgen Lemke, Christian Bergemann, Bernhard Sander, Reinhard Sohr, Dieter Ohlendorf, Michael Matthias, Peter Hohenberger, Hanno Riess, Norbert Haas, Renate Gürtler, Clinical Experiences with Magnetic Drug Targeting: A Phase I Study with 4′-Epidoxorubicin in 14 Patients with Advanced Solid Tumors Cancer Research. ,vol. 56, pp. 4686- 4693 ,(1996)
Samuel Krimm, Jagdeesh Bandekar, Vibrational spectroscopy and conformation of peptides, polypeptides, and proteins. Advances in Protein Chemistry. ,vol. 38, pp. 181- 364 ,(1986) , 10.1016/S0065-3233(08)60528-8
Haitao Chen, Armin D. Ebner, Axel J. Rosengart, Michael D. Kaminski, James A. Ritter, Analysis of magnetic drug carrier particle capture by a magnetizable intravascular stent: 1. Parametric study with single wire correlation Journal of Magnetism and Magnetic Materials. ,vol. 284, pp. 181- 194 ,(2004) , 10.1016/J.JMMM.2004.06.036
Axel J. Rosengart, Michael D. Kaminski, Haitao Chen, Patricia L. Caviness, Armin D. Ebner, James A. Ritter, Magnetizable implants and functionalized magnetic carriers: A novel approach for noninvasive yet targeted drug delivery Journal of Magnetism and Magnetic Materials. ,vol. 293, pp. 633- 638 ,(2005) , 10.1016/J.JMMM.2005.01.087
James A. Ritter, Misael O. Avilés, Armin D. Ebner, In vitro study of magnetic particle seeding for implant assisted-magnetic drug targeting Journal of Magnetism and Magnetic Materials. ,vol. 320, pp. 2640- 2646 ,(2008) , 10.1016/J.JMMM.2008.05.022
Erica M. Cherry, Peter G. Maxim, John K. Eaton, Particle size, magnetic field, and blood velocity effects on particle retention in magnetic drug targeting. Medical Physics. ,vol. 37, pp. 175- 182 ,(2009) , 10.1118/1.3271344