Implications of chimaeric non-co-linear transcripts

摘要: Deep sequencing of 'transcriptomes'--the collection all RNA transcripts produced at a given time--from worms to humans reveals that some are composed sequence segments not co-linear, with pieces coming from distant regions DNA, even different chromosomes. Some these 'chimaeric' formed by genetic rearrangements, but others arise during post-transcriptional events. The 'trans-splicing' process in lower eukaryotes is well understood, events higher not. existence such chimaeric RNAs has far-reaching implications for the potential information content genomes and way it arranged.