Assay of Human Thyroid Glands for Thyrocalcitonin Activity

摘要: Extracts of thyroid tissue from 15 consecutive patients undergoing surgery the neck were assayed for thyrocalcitonin in rats by a standardized biological assay method. Hypocalcemic activity was detected all 12 normal specimens, presumptive evidence presence human gland. Quantitative assays obtained 11 these cases showed range 9 to 170 U/g gland with mean 42 U/g, which is approximately 1% concentration found rat glands, same No hypocalcemic 2 adenomas and 1 hyperplastic at dose levels injected, equivalent 200 mg tissue/rat. Thyrocalcitonin low colloid goiter. The long-standing case pseudohypoparathyroidism 100 times higher than average Conclusions: 1) Thy...